/* Peptidekennis — basisstijl. Sober, leesbaar, wetenschappelijk. */

:root {
    --ink: #17202a;
    --ink-soft: #4a5768;
    --line: #dde3ea;
    --bg: #ffffff;
    --bg-soft: #f6f8fa;
    --accent: #16657a;
    --accent-soft: #e6f1f4;
    --warn-bg: #fdf6e7;
    --warn-line: #e4c97a;
    --radius: 10px;
    --wrap: 74rem;
    --measure: 42rem;
}

* { box-sizing: border-box; }

html { scroll-behavior: smooth; }

body {
    margin: 0;
    background: var(--bg);
    color: var(--ink);
    font: 400 17px/1.65 -apple-system, BlinkMacSystemFont, "Segoe UI", Inter, Roboto,
          "Helvetica Neue", Arial, sans-serif;
    -webkit-font-smoothing: antialiased;
}

.wrap { max-width: var(--wrap); margin: 0 auto; padding: 0 1.25rem; }

a { color: var(--accent); text-decoration-thickness: 1px; text-underline-offset: 2px; }
a:hover { color: #0f4c5c; }

.skip {
    position: absolute; left: -9999px; top: 0; background: var(--ink); color: #fff;
    padding: .6rem 1rem; z-index: 100;
}
.skip:focus { left: 0; }

.visually-hidden {
    position: absolute; width: 1px; height: 1px; overflow: hidden;
    clip: rect(0 0 0 0); white-space: nowrap;
}

/* ---------- header ---------- */
.site-header { border-bottom: 1px solid var(--line); background: #fff; position: sticky; top: 0; z-index: 20; }
.header-inner { display: flex; align-items: center; gap: 1.25rem; padding-block: .85rem; flex-wrap: wrap; }

.brand { display: flex; align-items: center; gap: .65rem; text-decoration: none; color: var(--ink); }
.brand-mark {
    width: 26px; height: 26px; border-radius: 7px; flex: none;
    background: linear-gradient(135deg, var(--accent), #38a1b4);
    box-shadow: inset 0 0 0 3px rgba(255,255,255,.55);
}
.brand-text { display: flex; flex-direction: column; line-height: 1.15; }
.brand-text strong { font-size: 1.05rem; letter-spacing: -.01em; }
.brand-text small { color: var(--ink-soft); font-size: .74rem; }

.site-nav { display: flex; gap: 1.15rem; margin-left: auto; flex-wrap: wrap; }
.site-nav a { color: var(--ink-soft); text-decoration: none; font-size: .93rem; padding: .2rem 0; border-bottom: 2px solid transparent; }
.site-nav a:hover, .site-nav a.active { color: var(--ink); border-bottom-color: var(--accent); }

.lang-switch { display: flex; gap: .3rem; font-size: .8rem; }
.lang-switch a {
    text-decoration: none; color: var(--ink-soft); border: 1px solid var(--line);
    border-radius: 5px; padding: .1rem .42rem;
}
.lang-switch a.active { background: var(--ink); color: #fff; border-color: var(--ink); }

.menu-toggle {
    display: none; margin-left: auto; background: none; border: 1px solid var(--line);
    border-radius: 6px; font-size: 1.1rem; padding: .25rem .55rem; cursor: pointer;
}

@media (max-width: 860px) {
    .menu-toggle { display: block; }
    .site-nav { display: none; width: 100%; flex-direction: column; gap: .1rem; margin: .5rem 0 0; }
    .site-nav.open { display: flex; }
    .site-nav a { padding: .5rem 0; border-bottom: 1px solid var(--line); }
    .lang-switch { position: absolute; right: 4rem; top: 1rem; }
}

/* ---------- main ---------- */
main { padding: 2rem 0 4rem; }

.crumbs { font-size: .82rem; color: var(--ink-soft); margin-bottom: 1.5rem; }
.crumbs a { color: var(--ink-soft); }
.crumbs span { color: var(--ink); }

h1 { font-size: clamp(1.9rem, 1.3rem + 2vw, 2.6rem); line-height: 1.15; letter-spacing: -.02em; margin: 0 0 .5rem; }
h2 { font-size: 1.35rem; line-height: 1.25; margin: 2.4rem 0 .7rem; letter-spacing: -.01em; }
h3 { font-size: 1.08rem; margin: 1.6rem 0 .5rem; }

.doc { max-width: 52rem; }
.doc-head { margin-bottom: 1.5rem; }
.lead, .lead-block p { font-size: 1.12rem; color: var(--ink-soft); }
.aliases { font-size: .9rem; color: var(--ink-soft); margin: .2rem 0 .6rem; }

.prose { max-width: var(--measure); }
.prose p, .prose li { color: #22303f; }
.prose ul, .prose ol { padding-left: 1.15rem; }
.prose li { margin: .3rem 0; }
.prose h2:first-child { margin-top: 0; }
.prose hr { border: 0; border-top: 1px solid var(--line); margin: 2rem 0; }
.prose blockquote {
    margin: 1.4rem 0; padding: .1rem 1rem; border-left: 3px solid var(--line);
    color: var(--ink-soft);
}
.prose code { background: var(--bg-soft); padding: .1rem .3rem; border-radius: 4px; font-size: .9em; }

/* ---------- notice ---------- */
.notice {
    background: var(--warn-bg); border: 1px solid var(--warn-line); border-radius: var(--radius);
    padding: .35rem 1.1rem; margin: 1.5rem 0; max-width: var(--measure);
}
.notice blockquote { border: 0; margin: .7rem 0; padding: 0; color: #6b5416; font-size: .93rem; }
.notice-foot { margin-top: 2.5rem; }

/* ---------- factbox ---------- */
.factbox {
    background: var(--bg-soft); border: 1px solid var(--line); border-radius: var(--radius);
    padding: 1.1rem 1.25rem; margin: 1.75rem 0; max-width: var(--measure);
}
.factbox-title { font-size: .78rem; text-transform: uppercase; letter-spacing: .08em; color: var(--ink-soft); margin: 0 0 .75rem; }
.factbox dl { margin: 0; display: grid; gap: .55rem; }
.fact { display: grid; grid-template-columns: 12rem 1fr; gap: .5rem; font-size: .94rem; }
.fact dt { color: var(--ink-soft); }
.fact dd { margin: 0; }
@media (max-width: 620px) { .fact { grid-template-columns: 1fr; gap: .1rem; } }

/* ---------- badges & tags ---------- */
.badge {
    display: inline-block; font-size: .74rem; font-weight: 600; letter-spacing: .02em;
    padding: .12rem .5rem; border-radius: 999px; border: 1px solid;
}
.badge-not-approved { background: #fdecec; border-color: #f0b3b3; color: #97231f; }
.badge-prescription { background: #eef3fb; border-color: #b9cbe8; color: #24487e; }
.badge-approved { background: #eaf6ef; border-color: #a9d8bd; color: #1c6b3f; }

.tags { margin: .4rem 0 0; display: flex; flex-wrap: wrap; gap: .4rem; }
.tag {
    font-size: .78rem; background: var(--accent-soft); color: #10525f; text-decoration: none;
    padding: .15rem .55rem; border-radius: 999px;
}
.tag:hover { background: #d6e9ee; }

/* ---------- toc ---------- */
.toc {
    border-left: 2px solid var(--line); padding: .2rem 0 .2rem 1rem; margin: 1.75rem 0;
    max-width: var(--measure);
}
.toc-title { font-size: .76rem; text-transform: uppercase; letter-spacing: .08em; color: var(--ink-soft); margin: 0 0 .4rem; }
.toc ul { list-style: none; margin: 0; padding: 0; display: grid; gap: .2rem; }
.toc a { font-size: .92rem; text-decoration: none; }
.toc a:hover { text-decoration: underline; }

/* ---------- terms & sources ---------- */
.terms, .sources { max-width: var(--measure); margin-top: 2.4rem; }
.terms h2, .sources h2 { font-size: 1.05rem; margin-bottom: .4rem; }
.sources ol { padding-left: 1.15rem; font-size: .93rem; color: var(--ink-soft); }
.updated { font-size: .82rem; color: var(--ink-soft); margin-top: 2rem; }

/* ---------- lijst / grid ---------- */
.toolbar { display: flex; align-items: center; gap: 1rem; margin: 1.5rem 0 .75rem; flex-wrap: wrap; }
.search input {
    width: min(24rem, 100%); padding: .6rem .8rem; font-size: 1rem;
    border: 1px solid var(--line); border-radius: 8px; background: #fff;
}
.search input:focus { outline: 2px solid var(--accent-soft); border-color: var(--accent); }
.result-count { color: var(--ink-soft); font-size: .9rem; margin: 0; }

.chips { display: flex; flex-wrap: wrap; gap: .4rem; margin-bottom: 1.5rem; }
.chip {
    font: inherit; font-size: .84rem; cursor: pointer; background: #fff; color: var(--ink-soft);
    border: 1px solid var(--line); border-radius: 999px; padding: .25rem .7rem;
}
.chip:hover { border-color: var(--accent); color: var(--accent); }
.chip.active { background: var(--ink); border-color: var(--ink); color: #fff; }

.grid { display: grid; gap: 1rem; grid-template-columns: repeat(auto-fill, minmax(16.5rem, 1fr)); }
.card {
    display: block; text-decoration: none; color: inherit; background: #fff;
    border: 1px solid var(--line); border-radius: var(--radius); padding: 1rem 1.1rem 1.15rem;
    transition: border-color .15s ease, transform .15s ease, box-shadow .15s ease;
}
.card:hover { border-color: var(--accent); transform: translateY(-2px); box-shadow: 0 6px 18px rgba(20,40,60,.07); }
.card-top { display: block; min-height: 1.2rem; margin-bottom: .5rem; }
.card h3 { margin: 0 0 .35rem; font-size: 1.05rem; }
.card p { margin: 0; font-size: .9rem; color: var(--ink-soft); }
.empty { color: var(--ink-soft); }
.back { margin-top: 1.75rem; }

/* ---------- home ---------- */
.hero { padding: 1.5rem 0 .5rem; max-width: 48rem; }
.hero-actions { display: flex; gap: .7rem; flex-wrap: wrap; margin-top: 1.4rem; }
.btn {
    display: inline-block; background: var(--ink); color: #fff; text-decoration: none;
    padding: .6rem 1.1rem; border-radius: 8px; font-size: .95rem;
}
.btn:hover { background: #0d1723; color: #fff; }
.btn-ghost { background: #fff; color: var(--ink); border: 1px solid var(--line); }
.btn-ghost:hover { background: var(--bg-soft); color: var(--ink); }

.pillars { display: grid; gap: 1rem; grid-template-columns: repeat(auto-fit, minmax(15rem, 1fr)); margin: 2.5rem 0; }
.pillar {
    display: block; text-decoration: none; color: inherit; border: 1px solid var(--line);
    border-radius: var(--radius); padding: 1.1rem 1.2rem; background: var(--bg-soft);
}
.pillar:hover { border-color: var(--accent); }
.pillar h3 { margin: 0 0 .35rem; font-size: 1.02rem; }
.pillar p { margin: 0; font-size: .9rem; color: var(--ink-soft); }
.featured h2 { margin-top: 2.5rem; }

/* ---------- begrippenlijst ---------- */
.jump { display: flex; flex-wrap: wrap; gap: .35rem; margin: 1.5rem 0 2rem; }
.jump a {
    font-size: .82rem; text-decoration: none; border: 1px solid var(--line);
    border-radius: 999px; padding: .2rem .6rem; color: var(--ink-soft);
}
.jump a:hover { border-color: var(--accent); color: var(--accent); }
.term { padding-top: .5rem; border-top: 1px solid var(--line); margin-top: 1.75rem; scroll-margin-top: 5rem; }
.term h2 { font-size: 1.12rem; margin-top: .6rem; }
.terms-list { max-width: var(--measure); }

/* ---------- footer ---------- */
.site-footer { border-top: 1px solid var(--line); background: var(--bg-soft); padding: 2rem 0 3rem; margin-top: 3rem; }
.footer-disclaimer { max-width: var(--measure); font-size: .88rem; color: var(--ink-soft); }
.footer-disclaimer p { margin: 0 0 1rem; }
.footer-links { font-size: .88rem; margin: 1rem 0 .4rem; }
.footer-links a { color: var(--ink-soft); }
.copyright { font-size: .8rem; color: var(--ink-soft); margin: 0; }

h2[id], h3[id] { scroll-margin-top: 5rem; }